Tyrosinkinase Fyn

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Tyrosinkinase Fyn
Eigenschaften des menschlichen Proteins
Masse/Länge Primärstruktur 537 Aminosäuren
Kofaktor Mn2+
Isoformen B, T, P06421-3
Bezeichner
Gen-Name FYN
Externe IDs
Enzymklassifikation
EC, Kategorie 2.7.10.2, Tyrosinkinase
Reaktionsart Phosphorylierung von Tyrosinresten in Proteinen
Substrat Xaa-Tyr-Yaa + ATP
Produkte Xaa-TyrP-Yaa + ADP
Vorkommen
Homologie-Familie Hovergen
Übergeordnetes Taxon Wirbeltiere[1]
Orthologe
Mensch Hausmaus
Entrez 2534 14360
Ensembl ENSG00000010810 ENSMUSG00000019843
UniProt P06241 P39688
Refseq (mRNA) NM_002037 NM_001122892
Refseq (Protein) NP_002028 NP_001116364
Genlocus Chr 6: 111.66 – 111.87 Mb Chr 10: 39.37 – 39.57 Mb
PubMed-Suche 2534 14360

Die Tyrosinkinase Fyn ist ein Enzym in Wirbeltieren, das die Phosphorylierung mehrerer Proteine an der Aminosäure Tyrosin katalysiert (Tyrosinkinase). Diese Reaktion ist Teil von etwa einem Dutzend Signalwege, die unentbehrlich für die Embryonalentwicklung des Gehirns und dessen spätere Funktion sind. Beim Menschen kontrolliert Fyn das Wachstum der Axone und den Calciumgehalt von Zellen. Von den drei bekannten Isoformen wird 'B' besonders im Gehirn und 'T' in T-Zellen exprimiert.[2]

Interaktionen

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Für FYN wurden einige Interaktionen mit anderen Proteinen nachgewiesen.

Literatur

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Quellen, Zitatnachweise, Zeitschriftenartikel

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  1. ↑ Orthologe bei OMA
  2. ↑ UniProt P06421
  3. ↑ T Shima, Okumura N, Takao T, Satomi Y, Yagi T, Okada M, Nagai K: Interaction of the SH2 domain of Fyn with a cytoskeletal protein, beta-adducin. In: J. Biol. Chem. 276. Jahrgang, Nr. 45, November 2001, ISSN 0021-9258, S. 42233–40, doi:10.1074/jbc.M102699200, PMID 11526103.
  4. ↑ a b Corinna Klein, Kramer Eva-Maria, Cardine Anne-Marie, Schraven Burkhardt, Brandt Roland, Trotter Jacqueline: Process outgrowth of oligodendrocytes is promoted by interaction of fyn kinase with the cytoskeletal protein tau. In: J. Neurosci. 22. Jahrgang, Nr. 3. United States Februar 2002, S. 698–707, PMID 11826099.
  5. ↑ J C Donaldson, Dempsey P J, Reddy S, Bouton A H, Coffey R J, Hanks S K: Crk-associated substrate p130(Cas) interacts with nephrocystin and both proteins localize to cell-cell contacts of polarized epithelial cells. In: Exp. Cell Res. 256. Jahrgang, Nr. 1, April 2000, ISSN 0014-4827, S. 168–78, doi:10.1006/excr.2000.4822, PMID 10739664.
  6. ↑ S N Manié, Astier A, Haghayeghi N, Canty T, Druker B J, Hirai H, Freedman A S: Regulation of integrin-mediated p130(Cas) tyrosine phosphorylation in human B cells. A role for p59(Fyn) and SHP2. In: J. Biol. Chem. 272. Jahrgang, Nr. 25, Juni 1997, ISSN 0021-9258, S. 15636–41, doi:10.1074/jbc.272.25.15636, PMID 9188452.
  7. ↑ Taher E I Taher, Tjin Esther P M, Beuling Esther A, Borst Jannie, Spaargaren Marcel, Pals Steven T: c-Cbl is involved in Met signaling in B cells and mediates hepatocyte growth factor-induced receptor ubiquitination. In: J. Immunol. 169. Jahrgang, Nr. 7, Oktober 2002, ISSN 0022-1767, S. 3793–800, PMID 12244174.
  8. ↑ a b M Deckert, Elly C, Altman A, Liu Y C: Coordinated regulation of the tyrosine phosphorylation of Cbl by Fyn and Syk tyrosine kinases. In: J. Biol. Chem. 273. Jahrgang, Nr. 15, April 1998, ISSN 0021-9258, S. 8867–74, doi:10.1074/jbc.273.15.8867, PMID 9535867.
  9. ↑ M Kim, Tezuka T, Suziki Y, Sugano S, Hirai M, Yamamoto T: Molecular cloning and characterization of a novel cbl-family gene, cbl-c. In: Gene. 239. Jahrgang, Nr. 1, Oktober 1999, ISSN 0378-1119, S. 145–54, doi:10.1016/S0378-1119(99)00356-X, PMID 10571044.
  10. ↑ M M Huang, Bolen J B, Barnwell J W, Shattil S J, Brugge J S: Membrane glycoprotein IV (CD36) is physically associated with the Fyn, Lyn, and Yes protein-tyrosine kinases in human platelets. In: Proc. Natl. Acad. Sci. U.S.A. 88. Jahrgang, Nr. 17, September 1991, ISSN 0027-8424, S. 7844–8, doi:10.1073/pnas.88.17.7844, PMID 1715582, PMC 52400 (freier Volltext).
  11. ↑ H A Bull, Brickell P M, Dowd P M: Src-related protein tyrosine kinases are physically associated with the surface antigen CD36 in human dermal microvascular endothelial cells. In: FEBS Lett. 351. Jahrgang, Nr. 1, August 1994, ISSN 0014-5793, S. 41–4, doi:10.1016/0014-5793(94)00814-0, PMID 7521304.
  12. ↑ S Ilangumaran, Briol A, Hoessli D C: CD44 selectively associates with active Src family protein tyrosine kinases Lck and Fyn in glycosphingolipid-rich plasma membrane domains of human peripheral blood lymphocytes. In: Blood. 91. Jahrgang, Nr. 10, Mai 1998, ISSN 0006-4971, S. 3901–8, PMID 9573028.
  13. ↑ a b Jose Piedra, Miravet Susana, Castaño Julio, Pálmer Héctor G, Heisterkamp Nora, García de Herreros Antonio, Duñach Mireia: p120 Catenin-associated Fer and Fyn tyrosine kinases regulate beta-catenin Tyr-142 phosphorylation and beta-catenin-alpha-catenin Interaction. In: Mol. Cell. Biol. 23. Jahrgang, Nr. 7, April 2003, ISSN 0270-7306, S. 2287–97, doi:10.1128/MCB.23.7.2287-2297.2003, PMID 12640114, PMC 150740 (freier Volltext).
  14. ↑ T Kihara, Shimohama S, Sawada H, Honda K, Nakamizo T, Shibasaki H, Kume T, Akaike A: alpha 7 nicotinic receptor transduces signals to phosphatidylinositol 3-kinase to block A beta-amyloid-induced neurotoxicity. In: J. Biol. Chem. 276. Jahrgang, Nr. 17, April 2001, ISSN 0021-9258, S. 13541–6, doi:10.1074/jbc.M008035200, PMID 11278378.
  15. ↑ S A Courtneidge, Dhand R, Pilat D, Twamley G M, Waterfield M D, Roussel M F: Activation of Src family kinases by colony stimulating factor-1, and their association with its receptor. In: EMBO J. 12. Jahrgang, Nr. 3, März 1993, ISSN 0261-4189, S. 943–50, PMID 7681396, PMC 413295 (freier Volltext).
  16. ↑ V Cleghon, Morrison D K: Raf-1 interacts with Fyn and Src in a non-phosphotyrosine-dependent manner. In: J. Biol. Chem. 269. Jahrgang, Nr. 26, Juli 1994, ISSN 0021-9258, S. 17749–55, PMID 7517401.
  17. ↑ Maria Cruz Martinez, Ochiishi Tomoyo, Majewski Michael, Kosik Kenneth S: Dual regulation of neuronal morphogenesis by a delta-catenin-cortactin complex and Rho. In: J. Cell Biol. 162. Jahrgang, Nr. 1, Juli 2003, ISSN 0021-9525, S. 99–111, doi:10.1083/jcb.200211025, PMID 12835311, PMC 2172717 (freier Volltext).
  18. ↑ a b T Tezuka, Umemori H, Akiyama T, Nakanishi S, Yamamoto T: PSD-95 promotes Fyn-mediated tyrosine phosphorylation of the N-methyl-D-aspartate receptor subunit NR2A. In: Proc. Natl. Acad. Sci. U.S.A. 96. Jahrgang, Nr. 2, Januar 1999, ISSN 0027-8424, S. 435–40, doi:10.1073/pnas.96.2.435, PMID 9892651, PMC 15154 (freier Volltext).
  19. ↑ a b Xiao-Yu Hou, Zhang Guang-Yi, Yan Jing-Zhi, Chen Min, Liu Yong: Activation of NMDA receptors and L-type voltage-gated calcium channels mediates enhanced formation of Fyn-PSD95-NR2A complex after transient brain ischemia. In: Brain Res. 955. Jahrgang, Nr. 1–2, November 2002, ISSN 0006-8993, S. 123–32, doi:10.1016/S0006-8993(02)03376-0, PMID 12419528.
  20. ↑ F Sotgia, Lee H, Bedford M T, Petrucci T, Sudol M, Lisanti M P: Tyrosine phosphorylation of beta-dystroglycan at its WW domain binding motif, PPxY, recruits SH2 domain containing proteins. In: Biochemistry. 40. Jahrgang, Nr. 48, Dezember 2001, ISSN 0006-2960, S. 14585–92, doi:10.1021/bi011247r, PMID 11724572.
  21. ↑ S Choi, Park S: Phosphorylation at Tyr-838 in the kinase domain of EphA8 modulates Fyn binding to the Tyr-615 site by enhancing tyrosine kinase activity. In: Oncogene. 18. Jahrgang, Nr. 39, September 1999, ISSN 0950-9232, S. 5413–22, doi:10.1038/sj.onc.1202917, PMID 10498895.
  22. ↑ J Wenzel, Sanzenbacher R, Ghadimi M, Lewitzky M, Zhou Q, Kaplan D R, Kabelitz D, Feller S M, Janssen O: Multiple interactions of the cytosolic polyproline region of the CD95 ligand: hints for the reverse signal transduction capacity of a death factor. In: FEBS Lett. 509. Jahrgang, Nr. 2, Dezember 2001, ISSN 0014-5793, S. 255–62, doi:10.1016/S0014-5793(01)03174-X, PMID 11741599.
  23. ↑ M Hane, Lowin B, Peitsch M, Becker K, Tschopp J: Interaction of peptides derived from the Fas ligand with the Fyn-SH3 domain. In: FEBS Lett. 373. Jahrgang, Nr. 3, Oktober 1995, ISSN 0014-5793, S. 265–8, doi:10.1016/0014-5793(95)01051-F, PMID 7589480.
  24. ↑ A J da Silva, Janssen O, Rudd C E: T cell receptor zeta/CD3-p59fyn(T)-associated p120/130 binds to the SH2 domain of p59fyn(T). In: J. Exp. Med. 178. Jahrgang, Nr. 6, Dezember 1993, ISSN 0022-1007, S. 2107–13, doi:10.1084/jem.178.6.2107, PMID 7504057, PMC 2191307 (freier Volltext).
  25. ↑ a b A Marie-Cardine, Hendricks-Taylor L R, Boerth N J, Zhao H, Schraven B, Koretzky G A: Molecular interaction between the Fyn-associated protein SKAP55 and the SLP-76-associated phosphoprotein SLAP-130. In: J. Biol. Chem. 273. Jahrgang, Nr. 40, Oktober 1998, ISSN 0021-9258, S. 25789–95, doi:10.1074/jbc.273.40.25789, PMID 9748251.
  26. ↑ Rami Yaka, He Dao-Yao, Phamluong Khanhky, Ron Dorit: Pituitary adenylate cyclase-activating polypeptide (PACAP(1-38)) enhances N-methyl-D-aspartate receptor function and brain-derived neurotrophic factor expression via RACK1. In: J. Biol. Chem. 278. Jahrgang, Nr. 11, März 2003, ISSN 0021-9258, S. 9630–8, doi:10.1074/jbc.M209141200, PMID 12524444.
  27. ↑ Rami Yaka, Thornton Claire, Vagts Alicia J, Phamluong Khanhky, Bonci Antonello, Ron Dorit: NMDA receptor function is regulated by the inhibitory scaffolding protein, RACK1. In: Proc. Natl. Acad. Sci. U.S.A. 99. Jahrgang, Nr. 8, April 2002, ISSN 0027-8424, S. 5710–5, doi:10.1073/pnas.062046299, PMID 11943848, PMC 122836 (freier Volltext).
  28. ↑ Juan Ma, Zhang Guang-Yi: Lithium reduced N-methyl-D-aspartate receptor subunit 2A tyrosine phosphorylation and its interactions with Src and Fyn mediated by PSD-95 in rat hippocampus following cerebral ischemia. In: Neurosci. Lett. 348. Jahrgang, Nr. 3, September 2003, ISSN 0304-3940, S. 185–9, doi:10.1016/S0304-3940(03)00784-5, PMID 12932824.
  29. ↑ N Takagi, Cheung H H, Bissoon N, Teves L, Wallace M C, Gurd J W: The effect of transient global ischemia on the interaction of Src and Fyn with the N-methyl-D-aspartate receptor and postsynaptic densities: possible involvement of Src homology 2 domains. In: J. Cereb. Blood Flow Metab. 19. Jahrgang, Nr. 8, August 1999, ISSN 0271-678X, S. 880–8, doi:10.1097/00004647-199908000-00007, PMID 10458595.
  30. ↑ S C Bunnell, Diehn M, Yaffe M B, Findell P R, Cantley L C, Berg L J: Biochemical interactions integrating Itk with the T cell receptor-initiated signaling cascade. In: J. Biol. Chem. 275. Jahrgang, Nr. 3, Januar 2000, ISSN 0021-9258, S. 2219–30, doi:10.1074/jbc.275.3.2219, PMID 10636929.
  31. ↑ S C Bunnell, Henry P A, Kolluri R, Kirchhausen T, Rickles R J, Berg L J: Identification of Itk/Tsk Src homology 3 domain ligands. In: J. Biol. Chem. 271. Jahrgang, Nr. 41, Oktober 1996, ISSN 0021-9258, S. 25646–56, doi:10.1074/jbc.271.41.25646, PMID 8810341.
  32. ↑ P P Sayeski, Ali M S, Safavi A, Lyles M, Kim S O, Frank S J, Bernstein K E: A catalytically active Jak2 is required for the angiotensin II-dependent activation of Fyn. In: J. Biol. Chem. 274. Jahrgang, Nr. 46, November 1999, ISSN 0021-9258, S. 33131–42, doi:10.1074/jbc.274.46.33131, PMID 10551884.
  33. ↑ Chitose Oneyama, Nakano Hirofumi, Sharma Sreenath V: UCS15A, a novel small molecule, SH3 domain-mediated protein-protein interaction blocking drug. In: Oncogene. 21. Jahrgang, Nr. 13, März 2002, ISSN 0950-9232, S. 2037–50, doi:10.1038/sj.onc.1205271, PMID 11960376.
  34. ↑ N Fusaki, Iwamatsu A, Iwashima M, Fujisawa J i: Interaction between Sam68 and Src family tyrosine kinases, Fyn and Lck, in T cell receptor signaling. In: J. Biol. Chem. 272. Jahrgang, Nr. 10, März 1997, ISSN 0021-9258, S. 6214–9, doi:10.1074/jbc.272.10.6214, PMID 9045636.
  35. ↑ Juhani Lahdenperä, Kilpeläinen Pekka, Liu Xiao Li, Pikkarainen Timo, Reponen Paula, Ruotsalainen Vesa, Tryggvason Karl: Clustering-induced tyrosine phosphorylation of nephrin by Src family kinases. In: Kidney Int. 64. Jahrgang, Nr. 2, August 2003, ISSN 0085-2538, S. 404–13, doi:10.1046/j.1523-1755.2003.00097.x, PMID 12846735.
  36. ↑ Rakesh Verma, Wharram Bryan, Kovari Iulia, Kunkel Robin, Nihalani Deepak, Wary Kishore K, Wiggins Roger C, Killen Paul, Holzman Lawrence B: Fyn binds to and phosphorylates the kidney slit diaphragm component Nephrin. In: J. Biol. Chem. 278. Jahrgang, Nr. 23, Juni 2003, ISSN 0021-9258, S. 20716–23, doi:10.1074/jbc.M301689200, PMID 12668668.
  37. ↑ T Brdicka, Pavlistová D, Leo A, Bruyns E, Korínek V, Angelisová P, Scherer J, Shevchenko A, Hilgert I, Cerný J, Drbal K, Kuramitsu Y, Kornacker B, Horejsí V, Schraven B: Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), a novel ubiquitously expressed transmembrane adaptor protein, binds the protein tyrosine kinase csk and is involved in regulation of T cell activation. In: J. Exp. Med. 191. Jahrgang, Nr. 9, Mai 2000, ISSN 0022-1007, S. 1591–604, doi:10.1084/jem.191.9.1591, PMID 10790433, PMC 2213442 (freier Volltext).
  38. ↑ I Gout, Dhand R, Panayotou G, Fry M J, Hiles I, Otsu M, Waterfield M D: Expression and characterization of the p85 subunit of the phosphatidylinositol 3-kinase complex and a related p85 beta protein by using the baculovirus expression system. In: Biochem. J. 288 ( Pt 2). Jahrgang, Dezember 1992, ISSN 0264-6021, S. 395–405, PMID 1334406, PMC 1132024 (freier Volltext).
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  40. ↑ Magdalena M. Gorska, Susan J. Stafford, Osman Cen, Sanjiv Sur, Rafeul Alam: Unc119, a Novel Activator of Lck/Fyn, Is Essential for T Cell Activation. In: The Journal of Experimental Medicine. Band 199, Nr. 3, 2004, ISSN 0022-1007, S. 369–379, doi:10.1084/jem.20030589, PMID 14757743, PMC 2211793 (freier Volltext).
  41. ↑ Samantha Messina, Onofri Franco, Bongiorno-Borbone Lucilla, Giovedì Silvia, Valtorta Flavia, Girault Jean-Antoine, Benfenati Fabio: Specific interactions of neuronal focal adhesion kinase isoforms with Src kinases and amphiphysin. In: J. Neurochem. 84. Jahrgang, Nr. 2, Januar 2003, ISSN 0022-3042, S. 253–65, doi:10.1046/j.1471-4159.2003.01519.x, PMID 12558988.
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  46. ↑ Sachiko Taniguchi, Liu Hui, Nakazawa Takanobu, Yokoyama Kazumasa, Tezuka Tohru, Yamamoto Tadashi: p250GAP, a neural RhoGAP protein, is associated with and phosphorylated by Fyn. In: Biochem. Biophys. Res. Commun. 306. Jahrgang, Nr. 1, Juni 2003, ISSN 0006-291X, S. 151–5, doi:10.1016/S0006-291X(03)00923-9, PMID 12788081.
  47. ↑ Chengjun Li, Iosef Cristiana, Jia Christina Y H, Han Victor K M, Li Shawn Shun-Cheng: Dual functional roles for the X-linked lymphoproliferative syndrome gene product SAP/SH2D1A in signaling through the signaling lymphocyte activation molecule (SLAM) family of immune receptors. In: J. Biol. Chem. 278. Jahrgang, Nr. 6, Februar 2003, ISSN 0021-9258, S. 3852–9, doi:10.1074/jbc.M206649200, PMID 12458214.
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  50. ↑ Liangtang Wu, Yu Zhenbao, Shen Shi-Hsiang: SKAP55 recruits to lipid rafts and positively mediates the MAPK pathway upon T cell receptor activation. In: J. Biol. Chem. 277. Jahrgang, Nr. 43, Oktober 2002, ISSN 0021-9258, S. 40420–7, doi:10.1074/jbc.M206023200, PMID 12171928.
  51. ↑ D A Linseman, Heidenreich K A, Fisher S K: Stimulation of M3 muscarinic receptors induces phosphorylation of the Cdc42 effector activated Cdc42Hs-associated kinase-1 via a Fyn tyrosine kinase signaling pathway. In: J. Biol. Chem. 276. Jahrgang, Nr. 8, Februar 2001, ISSN 0021-9258, S. 5622–8, doi:10.1074/jbc.M006812200, PMID 11087735.
  52. ↑ Y Iwasaki, Gay B, Wada K, Koizumi S: Association of the Src family tyrosine kinase Fyn with TrkB. In: J. Neurochem. 71. Jahrgang, Nr. 1, Juli 1998, ISSN 0022-3042, S. 106–11, doi:10.1046/j.1471-4159.1998.71010106.x, PMID 9648856.
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  56. ↑ S Banin, Gout I, Brickell P: Interaction between Wiskott-Aldrich Syndrome protein (WASP) and the Fyn protein-tyrosine kinase. In: Mol. Biol. Rep. 26. Jahrgang, Nr. 3, August 1999, ISSN 0301-4851, S. 173–7, doi:10.1023/A:1006954206151, PMID 10532312.
  57. ↑ O M Rivero-Lezcano, Marcilla A, Sameshima J H, Robbins K C: Wiskott-Aldrich syndrome protein physically associates with Nck through Src homology 3 domains. In: Mol. Cell. Biol. 15. Jahrgang, Nr. 10, Oktober 1995, ISSN 0270-7306, S. 5725–31, PMID 7565724, PMC 230823 (freier Volltext).
  58. ↑ E N Neumeister, Zhu Y, Richard S, Terhorst C, Chan A C, Shaw A S: Binding of ZAP-70 to phosphorylated T-cell receptor zeta and eta enhances its autophosphorylation and generates specific binding sites for SH2 domain-containing proteins. In: Mol. Cell. Biol. 15. Jahrgang, Nr. 6, Juni 1995, ISSN 0270-7306, S. 3171–8, PMID 7760813, PMC 230549 (freier Volltext).
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