Benutzerin:Kersti Nebelsiek/16

Leuzismus

Loci

DogSpotKITednrb.pdf

• M. A. E. VAN HAGEN,J.VAN DER KOLK,M.A.M.BARENDSE,S.IMHOLZ,P.A.J.LEEGWATER, B. W. KNOL, AND B. A. VAN OOST : Analysis of the Inheritance of White Spotting and the Evaluation of KIT and EDNRB as Spotting Loci in Dutch Boxer Dogs Journal of Heredity 2004:95(6):526–531 a 2004, The American Genetic Association doi:10.1093/jhered/esh083

• Exclusion of EDNRBand KITas the basis for white spotting in Border Collies

• Danika Metallinos und Jasper Rine: Exclusion of EDNRBand KITas the basis for white spotting in Border Collies GenomeBiology2000, 1(2):research0004.1–0004.4 http://genomebiology.com/2000/1/2/research/0004.1

Steel, MGF

Bos Taurus

KITLG KIT ligand (Bos taurus)

• NCBI: KITLG KIT ligand (Bos taurus), GeneID: 281885, Stand: 24-Jan-2007

Andere Namen: KITLG; MGF, KIT ligand, mast cell growth factor

MGF mast cell growth factor (white heifer disease) (Bos taurus)

• NCBI: MGF mast cell growth factor (white heifer disease) (Bos taurus), GeneID: 280856, Stand: 04-Oct-2006, http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=full_report&list_uids=280856

Microsatellite mapping of the bovine roan locus: a major determinant of White Heifer disease.

• Charlier C, Denys B, Belanche JI, Coppieters W, Grobet L, Mni M, Womack J, Hanset R, Georges M: Microsatellite mapping of the bovine roan locus: a major determinant of White Heifer disease. Mamm Genome. 1996 Feb;7(2):138-42, PMID 8835531

In the Belgian Blue Cattle breed, coat color variation is mainly under the influence of a single autosomal locus, the roan locus, characterized by a pair of codominant alleles: r+ (black) and R (white). Heterozygous r+R animals have intermingled black and white hairs, yielding the "blue" phenotype typical of the breed. Major interest for the roan locus stems from its pleiotropic effect on fertility, owing to the critical role of the R allele in the determinism of White Heifer Disease. We describe the linkage mapping of the roan locus to bovine Chromosome (Chr) 5, in the interval between microsatellite markers BPI and AGLA293, with an associated lodscore of 11.2. Moreover, we map a candidate gene, the Steel locus coding for the mast cell growth factor, to bovine Chr 5.

A missense mutation in the bovine MGF gene is associated with the roan phenotype in Belgian Blue and Shorthorn cattle

• Seitz JJ, Schmutz SM, Thue TD, Buchanan FC: A missense mutation in the bovine MGF gene is associated with the roan phenotype in Belgian Blue and Shorthorn cattle. Mamm Genome. 1999 Jul;10(7):710-2, PMID 10384045, http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=10384045&query_hl=19&itool=pubmed_docsum

Notitzen

• Chinese White Rongchang Pig Does Not Have the Dominant White Allele of KIT but Has the Dominant Black Allele of MC1R. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17150979&query_hl=23&itool=pubmed_docsum
• Grahn RA, Lemesch BM, Millon LV, Matise T, Rogers QR, Morris JG, Fretwell N, Bailey SJ, Batt RM, Lyons LA:Localizing the X-linked orange colour phenotype using feline resource families. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=15670134&query_hl=43&itool=pubmed_docsum
• Mitf: verwandte verfolgen: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=17121617
• The "spotted" locus maps to bovine chromosome 6 in a Hereford-Cross population. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=9987932&query_hl=19&itool=pubmed_docsum

Schwein

• Schwein: In the pig, we have described seven MC1R alleles controlling four different coat color phenotypes (wild type, dominant black, black spotting, and recessive red). The most interesting allele is the one causing black spotting because it carries two causative mutations, a frameshift and a missense mutation. The frameshift mutation is somatically unstable, and the black spots reflect somatic reversion events restoring the reading frame.
• Schwein: A previous study indicated that a missense mutation (D298N) in pig MC4R has an effect on fatness, growth, and feed intake. We could not confirm this association using an intercross between the wild boar and Large White domestic pigs, but it is possible that our F2 generation was too small to detect the rather modest effect reported for this polymorphism.
• LEIF ANDERSSON: Melanocortin Receptor Variants with Phenotypic Effects in Horse, Pig, and Chicken Annals of the New York Academy of Sciences 994:313-318 (2003)