Diskussion:Sulfanilamid

Sulfanilamid oder Sulfonilamid

Lemma heißt Sulfanilamid, im Text stand mehrfach Sulfonilamid. Habe es geändert, bitte aber um Prüfung.--Blaufisch 20:09, 15. Mär. 2007 (CET)

Discovery of Sulfanilamid

Bonjour à tous. If you keep a few lines upon history and discovery of sulfanilamid, I think it is necessary you mention Daniel Bovet. Sulfanilamid, discovered by Gelmo in 1908, was not introduced by Domagk. When Domagk introduced his drug, Prontosil (sulfamidochrysoïdine), (G. Domagk, « Ein Beitrag zur Chemotherapie der bakteriellen Infektionen », Deutsch. Med. Wschr., 61, 15 février 1935, p. 250), he did not think that its colorless part was active, but only the dye element. Some months later, Daniel Bovet (with Jacques and Thérèse Tréfouël and Federico Nitti, in Ernest Fourneau's laboratory at Pasteur Institute) discovered that Prontosil was cut into two parts by living organismes, and that only sulfa part (p-aminophenylsulfamid) was active against bacterias (J. et T. Tréfouël, F. Nitti et D. Bovet, « Activité du p.aminophénylsulfamide sur l’infection streptococcique expérimentale de la souris et du lapin », C. R. Soc. Biol., 120, 23 novembre 1935, p. 756). The following year, in october, Domagk published on sulfanilamid (G. Domagk, « Chemotherapie der Streptokokkeninfektionen », Klin. Wschr., 15, 31 oct. 1936, p. 1585.), before he introduced Prontosil album, which is not else than Bovet's sulfanilamid itself (later French Septoplix). The discovery of therapeutical properties of sulfonamids has to be given to Bovet and not to be reported to Domagk's Prontosil.

I hope some of you will give attention to this post. Très cordialement. --Thierry 13:28, 6. Aug. 2010 (CEST)

Some synonyms

Hello. As the page does not tell anything about the actual discovering of medical properties of sulfanilamid, a discovering which today is known as being due to Bovet and not to Domagk, and as I am unable to publish in another language than French, I only dare to give two more early names of sulfanilamid in the info-box. Those two names remind us where, when, by whom and in which circumstances the compound (of which sulfamidochrysoidin was only a prodrug, and which Domack had never thought, far from it, as being the active part of his Prontosil) was discovered and introduced. If you like to learn some more about it, you may go to the article in French and, starting from it, to the Babelian library. Best regards. --Thierry (Diskussion) 14:27, 15. Mär. 2013 (CET)